Mend It or End It
نویسنده
چکیده
On February 10, 2003, the American Bar Association (ABA) approved the revised edition of its Guidelines for the Appointment and Performance of Defense Counsel in Death Penalty Cases. Their purpose is to articulate the “national standard of practice for the defense of capital cases;” they “are not aspirational. Instead, they embody the current consensus about what is required to provide effective defense representation in capital cases.” The Guidelines are not the work of an organization opposed to capital punishment, nor are they intended to address the issue of its desirability. Rather, their core is a mandate that “any jurisdiction wishing to impose a death sentence must at minimum provide representation that comports with these Guidelines.”
منابع مشابه
Massive endocytosis triggered by surface membrane palmitoylation under mitochondrial control in BHK fibroblasts
Large Ca transients cause massive endocytosis (MEND) in BHK fibroblasts by nonclassical mechanisms. We present evidence that MEND depends on mitochondrial permeability transition pore (PTP) openings, followed by coenzyme A (CoA) release, acyl CoA synthesis, and membrane protein palmitoylation. MEND is blocked by inhibiting mitochondrial Ca uptake or PTP openings, depleting fatty acids, blocking...
متن کاملAfter the RCT: who comes to a family-based intervention for childhood overweight or obesity when it is implemented at scale in the community?
BACKGROUND When implemented at scale, the impact on health and health inequalities of public health interventions depends on who receives them in addition to intervention effectiveness. METHODS The MEND 7-13 (Mind, Exercise, Nutrition…Do it!) programme is a family-based weight management intervention for childhood overweight and obesity implemented at scale in the community. We compare the ch...
متن کاملMassive calcium–activated endocytosis without involvement of classical endocytic proteins
We describe rapid massive endocytosis (MEND) of >50% of the plasmalemma in baby hamster kidney (BHK) and HEK293 cells in response to large Ca transients. Constitutively expressed Na/Ca exchangers (NCX1) are used to generate Ca transients, whereas capacitance recording and a membrane tracer dye, FM 4-64, are used to monitor endocytosis. With high cytoplasmic adenosine triphosphate (ATP; >5 mM), ...
متن کامل[Development of a novel artificial gene delivery system multifunctional envelope-type nano device for gene therapy].
For efficient gene delivery to the nucleus, nonviral vectors need to overcome several barriers such as the plasma membrane, endosomal membrane, and nuclear membrane. To overcome these obstacles, it is necessary to equip the delivery system with various functional devices. However, it is difficult to package all such functional devices into a single system to exert each of their functions at the...
متن کاملThe systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice.
Efficient delivery continues to be a challenge in microRNA (miRNA) therapeutics. We utilized a pH-sensitive multifunctional envelope-type nano device (MEND) containing a pH-sensitive lipid YSK05 (YSK05-MEND) to regulate liver specific miRNA-122 (miR-122). Anti-microRNA oligonucleotides including 2′-OMe and phosphorothioate modifications against miR-122 (AMO122) were encapsulated in the YSK05-ME...
متن کامل[Development of various multifunctional envelope-type nano device MEND based on novel assembly technologies].
Non-viral vectors need to overcome several barriers such as the plasma membrane, the endosomal membrane and the nuclear membrane for efficient gene delivery to the nucleus of target cells. To overcome these obstacles, the delivery system must be equipped with various functional devices. However, it is difficult to package all these needed devices into a single system to exert each of their func...
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